There is little direct reuse of health care data for (bio)medical research. Instead, research projects still manually re-enter the required health care data into research systems. The purpose of this programme line is to change this situation and, ultimately, make all clinical data from UMCs available for every valid research question across the country with full protection of patient privacy and without impacting clinical care. Therefore this subproject has close connections with the NFU programme ‘Registration at the source’ which regulates the clear, one-off registration of patient data. The first results will comprise a series of pilot projects together with Registration at the source and TraIT.